painless postfix on mac os
Sometime during the past year I got a few things working on my Mac that really made my life simpler: offlineimap, mutt, and postfix. offlineimap is a Python program for syncing an IMAP store to a set of Maildirs. It works bidirectionally and its installer is simple and just works. (Configuration was a little weird, but even that is very simple.) mutt is my MUA of choice, and its installation is even simpler.
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